Mitochondrial DNA

Mitochondrial DNA (mtDNA) is particularly vulnerable to oxidative damage due to its proximity to the electron transport chain, where reactive oxygen species are generated. Damaged mtDNA can lead to impaired mitochondrial function, which culminates in cellular dysfunction and contributes to cardiovascular disease, neurodegenerative conditions, and cancer.

RayBiotech’s Mitochondrial DNA Damage Quantification Kits and Absolute DNA Copy Number Quantification Kits are qPCR assays designed to help researchers quantify mitochondrial dysfunction in models of aging and chronic disease as well as gain insights into cellular energy capacity and mitochondrial health. Both kit formats are available for human, mouse, and rat samples. Pair these kits with our Mitochondrial DNA Isolation Kit to isolate mtDNA from a variety of cell types and tissues in high yield and purity, without nuclear DNA contamination.