Recombinant SARS-CoV-2 Spike Protein, S1 Subunit derived from E.coli
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Product Description


Size 100 ug, 250 ug
Protein Name / Synonyms SARS-CoV-2 Spike Protein, S1 Subunit, S protein, spike protein
Accession Number QHD43416
Concentration (lot specific) Lot specific (see the label on the vial), determined by Bradford protein assay.
Purity >80 %
Format Liquid
Formulation Filtered solution in 50 mM Tris-HCl, 500 mM NaCl, 600 mM arginine, 2 mM oxidized glutathione, 4 mM reduced glutathione, 0.2% PEG4000, 10% glycerol, 2 mM DTT, 20 mM Hepes (pH 9).
Purity Determined By SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Expressed Region Val16 - Gln690
Expression System E.Coli
Tag N-terminal histidine tag
Purification His-tag affinity purification by immobilized metal ion affinity chromatography (IMAC)
Molecular Weight ∼75 kDa
Species SARS-CoV-2

Stability & Storage

Ice packs
Upon arrival, the protein may be stored for 2 weeks at 4 °C. For long term storage, it is recommended to store at -20 °C or -80 °C in appropriate aliquots. Avoid repeated freeze-thaw cycles.

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S1 Subunit Protein (RBD) with C-terminal Fc tag
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A Vojdani and D Kharrazian. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol. 217, 108480 (2020).
J Yu, et al. Direct activation of the alternative complement pathway by SARS-CoV-2 spike protein is blocked by factor D inhibition. Blood. 2020 Sep 2;blood.2020008248 (2020).
Ramanujam, A.; Almodovar, S.; Botte, G.G. Ultra-Fast Electrochemical Sensor for Point-of-Care COVID-19 Diagnosis Using Non-Invasive Saliva Sampling.?Processes?2021,?9, 1236.
Hud?k A, et al. Contribution of Syndecans to the Cellular Entry of SARS-CoV-2. Int J Mol Sci (2021).
Prompetchara E, et al. DNA vaccine candidate encoding SARS-CoV-2 spike proteins elicited potent humoral and Th1 cell-mediated immune responses in mice. PLOS ONE 16(3): e0248007 (2021).
Suzuki YJ, et al. SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells. Vascul Pharmacol, 137 (2021).
Vojdani A, et al. Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases. Front Immunol (2021).
Bortolotti D, et al. SARS-CoV-2 spike 1 protein controls natural killer cell activation via the HLA-E/NKG2A pathway. Cells (2020).
  1. Great product
    This is a SARS-CoV-2 spike protein S1 subunit that is not glycosylated. This protein does not bind to ACE2, but can elicit other biological events. Thus, it is a great tool to understand spike protein biology.

    Review by

    from Georgetown University,


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