Anti-ABCD1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P33897
Gene Id	215
Gene Symbols	ABCD1
Protein Name / Synonyms	ABCD1 (Center)
Clonality	Polyclonal
Preparation	This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
Concentration (lot specific)	0.300 mg/ml
Recommended Applications	Western Blotting, IHC-P, FC
Research Area	Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.

Specificity

Predicted Reactivity

Mouse

Other Names

ABCD1; ALD; ATP-binding cassette sub-family D member 1; Adrenoleukodystrophy protein

NCBI Accession #

NP_000024.2

Other Accession #

P48410; NP_000024.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

82937

Recommended Dilutions

WB: 1:1000; IHC: 1:50-100; FC: 1:10-50

	ABCD1 Antibody (Center) (Cat# 102-10656) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ABCD1 antibody detected the ABCD1 protein (arrow).
	ABCD1 antibody (Center) (Cat# 102-10656) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ABCD1 antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
	ABCD1 Antibody (Center) (Cat# 102-10656) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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