Anti-Activin A Receptor Type IC (ACVR1C) (N-term A48) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q8K348\|Q8NER5
Gene Id	130399
Gene Symbols	ACVR1C
Protein Name / Synonyms	Activin receptor type-1C, Activin receptor type IC, ACTR-IC, Activin receptor-like kinase 7, ALK-7, ACVR1C (HGNC:18123)
Clonality	Polyclonal
Clone	RB8195
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting, IHC-P
Research Area	TGF-beta Signaling
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

Other Information

NCBI Accession #

NP_001104501.1;NP_001104502.1;NP_001104503.1;NP_660302.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Calculated Molecular Weight (Da)

54871

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of anti-ACVR1C Antibody (N-term A48) (Cat.#102-27173) in HepG2 and Hela cell line lysate (35ug/lane). ACVR1C (arrow) was detected using the purified Pab.

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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