Anti-AIRE (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O43918
Gene Id	326
Gene Symbols	AIRE
Protein Name / Synonyms	AIRE (Center)
Clonality	Polyclonal
Preparation	This AIRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	IF
Research Area	Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).

Specificity

Other Names

AIRE; APECED; Autoimmune regulator; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein

NCBI Accession #

NP_000374.1

Other Accession #

NP_000374.1; NP_000649.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

57727

Recommended Dilutions

WB: 1:1000; IF: 1:10-50

	AIRE Antibody (Center) (Cat# 102-10927) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the AIRE antibody detected the AIRE protein (arrow).
	Confocal immunofluorescent analysis of AIRE Antibody (Center)(Cat# 102-10927) with 293 cell followed by Alexa Fluor^® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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