Anti-AKTIP (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9H8T0
Gene Id	64400
Gene Symbols	AKTIP
Protein Name / Synonyms	AKTIP(C-term)
Clonality	Polyclonal
Preparation	This AKTIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 262-288 amino acids from the C-terminal region of human AKTIP.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Specificity

Predicted Reactivity

Mouse, Rat, Chicken, Monkey

Other Names

AKTIP; FTS; AKT-interacting protein; Ft1; Fused toes protein homolog

NCBI Accession #

NP_001012398.1;NP_071921.1

Other Accession #

Q5FVH4; Q64362; Q4R5E1; Q5ZJJ5; NP_001012398.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33128

Recommended Dilutions

WB: 1:1000

Western blot analysis of lysates from human heart tissue lysate, U-251 MG cell line (from left to right), using AKTIP Antibody (C-term)(Cat# 102-14256). 102-14256 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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