Anti-ALS2CR2 (C-term L289) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9C0K7
Gene Id	55437
Gene Symbols	STRADB
Protein Name / Synonyms	STE20-related kinase adapter protein beta, STRAD beta, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein, CALS-21, ILP-interacting protein, Pseudokinase ALS2CR2, STRADB, ALS2CR2, ILPIP
Clonality	Polyclonal
Clone	RB15723
Isotype	Kappa, Rabbit
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.

Other Information

NCBI Accession #

NP_001193793.1;NP_061041.2

Antigen Type

Synthetic Peptide

Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Calculated Molecular Weight (Da)

47026

Antigen Source

Human

Images

WB (1:1000)

Western blot analysis of ALS2CR2 (arrow) using ALS2CR2 Antibody (C-term L289) (Cat.#102-27175). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ALS2CR2 gene (Lane 2) (Origene Technologies).

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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