Anti-ASCL1 (Achaete-scute homolog 1) (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P50553
Gene Id	429
Gene Symbols	ASCL1
Protein Name / Synonyms	ASCL1 (Achaete-scute homolog 1) (C-term)
Clonality	Polyclonal
Preparation	This ASCL1 (Achaete-scute homolog 1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human ASCL1 (Achaete-scute homolog 1).
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

ACSL1, alternatively titled Hash1 or Mash1, is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. ACSL1 plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. The protein is highly expressed in medullary thyroid cancer and small cell lung cancer and may be a useful marker for these cancers. The presence of a CAG repeat in the gene suggests it may also play a role in tumor formation.

Specificity

Predicted Reactivity

Rat

Other Names

ASCL1; ASH1; BHLHA46; HASH1; Achaete-scute homolog 1; Class A basic helix-loop-helix protein 46

NCBI Accession #

NP_004307.2

Other Accession #

P19359; Q02067; NP_004307

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

25454

Recommended Dilutions

WB: 1:1000

The anti-Hash1 Pab (Cat#AP2019a) is used in Western blot to detect Hash1 in mouse lung tissue lysate.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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