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Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Rat |
| Host Species | Rabbit |
| Accession Number | Q13315 |
| Gene Id | 472 |
| Gene Symbols | ATM |
| Protein Name / Synonyms | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1, serine-protein kinase ATM |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | IF |
| Research Area | Cardiovascular Disease, Cancer, Autophagy, DNA Damage |
| Shipping Type | Blue ice |
| Storage | -20°C |
Background
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Dilutions
IF 1:50 - 1:200
Format
Calculated MW
350kDa
Observed MW
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1900-2000 of human ATM (NP_000042.3).
Modification
Unmodified
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.