Anti-BAG4 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O95429
Gene Id	9530
Gene Symbols	BAG4
Protein Name / Synonyms	BAG4 (C-term)
Clonality	Polyclonal
Preparation	This BAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.

Specificity

Predicted Reactivity

Mouse

Other Names

BAG4; SODD; BAG family molecular chaperone regulator 4; Bcl-2-associated athanogene 4; Silencer of death domains

NCBI Accession #

NP_001191807.1;NP_004865.1

Other Accession #

Q8CI61; NP_004865.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

49594

Recommended Dilutions

WB: 1:1000

BAG4 Antibody (C-term) (Cat# 102-12944) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BAG4 antibody detected the BAG4 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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