Anti-BAP1 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q92560
Gene Id	8314
Gene Symbols	BAP1
Protein Name / Synonyms	BAP1, HUCEP-13, UCHL2, hucep-6, BRCA1 associated protein 1
Clonality	Polyclonal
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.01% thimerosal, 50% glycerol, pH 7.3
Recommended Applications	Western Blotting, IHC
Research Area	Cancer, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Background

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

Dilutions

WB 1:500 - 1:2000
IHC 1:50 - 1:200

Format

Calculated MW

80kDa

Observed MW

Refer to figures

Immunogen

Recombinant funsion protein containing a sequence corresponding to amino acids 460-729 of human BAP1 (NP_004647.1).

Modification

Unmodified

Storage

-20°C

Images

Immunohistochemistry of paraffin-embedded human breast using BAP1 antibody (144-06533) at dilution of 1:150 (40x lens).
Immunohistochemistry - BAP1 Polyclonal Antibody (144-06533)

Immunohistochemistry of paraffin-embedded human breast cancer using BAP1 antibody (144-06533) at dilution of 1:150 (40x lens).
Immunohistochemistry - BAP1 Polyclonal Antibody (144-06533)

Expiration:

12 months from the date of shipment when stored properly.

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