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Anti-BBC3 Antibody
Catalog #: 144-64809
BBC3 pAb
Product Description
Specifications
| Size | 20 µL, 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | Q9BXH1|Q96PG8 |
| Gene Id | 27113 |
| Gene Symbols | BBC3 |
| Protein Name / Synonyms | BBC3, JFY-1, JFY1, PUMA, BCL2 binding component 3 |
| Isotype | IgG |
| Purity | Affinity purification |
| Buffers | PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
| Recommended Applications | Western Blotting, IHC, IF |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Background
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants.
Dilutions
WB 1:500 - 1:2000; IHC 1:50 - 1:100; IF 1:50 - 1:100
Format
Calculated MW
10kDa/14kDa/20kDa/26kDa
Observed MW
20kDa
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human BBC3 (NP_001120713.1).
Modification
Storage
Store at -20°. Avoid freeze / thaw cycles.
Images
Expiration:
12 months from the date of shipment when stored properly.