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Anti-Bcl-2 Antibody Cocktail
Catalog #: 188-10010-IHC
Mouse anti-Human Bcl2 Antibody Cocktail [IHC only]
Product Description
Specifications
| Size | 7 mL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Does not react with mouse and rat. Other species not known. |
| Host Species | Mouse |
| Accession Number | P10415 |
| Gene Id | 596 |
| Gene Symbols | BCL2 |
| Protein Name / Synonyms | Apoptosis regulator Bcl-2 |
| Immunogen | A synthetic peptide, aa 41-54 (GAAPAPGIFSSQPG) of the human protein was used as the immunogen for both antibodies in this Bcl2 antibody cocktail. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G purification |
| Concentration (lot specific) | Prediluted in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide, *For IHC use only* |
| Recommended Applications | Prediluted format : incubate for 30 min at RT (2) |
| Domain / Region / Terminus | Cytoplasmic, membrane |
| Research Area | Apoptosis, Autophagy |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
B-cell lymphoma 2 is an oncogene that regulates apoptosis, having both inducing and inhibiting functions. In cancer cells, Bcl2 binds pro-apoptotic proteins, preventing programmed cell death from occurring. Overexpression is seen in many cancers including lung, breast, prostate and lymphomas. In most follicular lymphomas, neoplastic germinal centers express high levels of the protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, Bcl2 antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies.
Storage
Store the Bcl2 antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.