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Anti-Beta Catenin Antibody, Sodium Azide Free
Catalog #: 188-10987-SAF
Mouse anti-Human/Cow/Dog/Chicken Beta Catenin Antibody [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | P35222 |
| Gene Id | 1499 |
| Gene Symbols | CTNNB1,CTNNB,OK,SW-CL.35,PRO2286 |
| Protein Name / Synonyms | Catenin beta-1 (Beta-catenin) |
| Immunogen | Chicken b-Catenin was used as the immunogen for the b-Catenin antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | Immunofluorescence: 1-2ug/ml Western Blotting: 1-2ug/ml |
| Domain / Region / Terminus | Cell surface, cytoplasmic, cell junctions |
| Research Area | Angiogenesis, Cardiovascular Disease, Cancer, Wnt-beta-Catenin Signaling |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. [RefSeq]
Storage
Store the b-Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.