Anti-Bi-Phospho-JNK1 (T183/Y185) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P45983
Gene Id	5599
Gene Symbols	MAPK8
Protein Name / Synonyms	Bi-Phospho-JNK1(T183/Y185)
Clonality	Polyclonal
Preparation	This JNK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T183/Y185 of human JNK1.
Concentration (lot specific)	0.400 mg/ml
Recommended Applications	Dot Blotting
Research Area	Autophagy
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Specificity

Predicted Reactivity

Mouse, Rat, Xenopus

Other Names

MAPK8; JNK1; PRKM8; SAPK1; SAPK1C; Mitogen-activated protein kinase 8; JNK-46; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1

NCBI Accession #

NP_001265476.1;NP_002741.1;NP_620634.1;NP_620637.1

Other Accession #

P49187; Q61831; P53779; Q8QHK8; P49185; Q91Y86; NP_620634.1; NP_620637.1; NP_002741.1; NP_620635.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

48296

Recommended Dilutions

DB: 1:500

Dot blot analysis of anti-Phospho-JNK1-T183/Y185 Phospho-specific Pab (Cat# 102-15553) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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