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ISO 13485:2016 cGMP
Anti-BID Antibody
Catalog #: 130-10027
Rabbit Anti-Human BID Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg, 1 mg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P55957 |
| Gene Id | 637 |
| Gene Symbols | BID |
| Protein Name / Synonyms | BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] |
| Clonality | Polyclonal |
| Preparation | Immunogen was synthetic peptide derived from human BID. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified by Protein A affinity chromatography. |
| Recommended Applications | ELISA (recommended work dilution= 1:5, 000) |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in glycine solution. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Description
BID, apoptic death agonist is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. The expression of BID is upregulated by the tumor suppressor p53, and BID has been shown to be involved in p53-mediated apoptosis. The p53 protein is a transcription factor that, when activated as part of the cell's response to stress, regulates many downstream target genes, including BID. The major proteolytic product p15 BID allows the release of cytochrome c by similarity. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis.
Storage/Stability
Store at -20°C. If intended for use within a month, may keep at 4°C. Minimize freeze-thaw cycles.
Expiration
12 months from the date of shipment when stored properly.