Anti-BMPR1B (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O00238
Gene Id	658
Gene Symbols	BMPR1B
Protein Name / Synonyms	BMPR1B (Center)
Clonality	Polyclonal
Preparation	This BMPR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-162 amino acids from the Central region of human BMPR1B.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension.

Specificity

Other Names

BMPR1B; Bone morphogenetic protein receptor type-1B; CD_antigen=CDw293; Flags: Precursor

NCBI Accession #

NP_001194.1;NP_001243721.1;NP_001243722.1;NP_001243723.1

Other Accession #

NP_001194.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

56930

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	BMPR1B Antibody (Center) (Cat# 102-11363) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the BMPR1B antibody detected the BMPR1B protein (arrow).
	BMPR1B Antibody (Center) (Cat# 102-11363)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of BMPR1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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