Brevetoxin (PbTx), or brevetoxins, are a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis. Brevetoxins are neurotoxins that bind to voltage-gated sodium channels in nerve cells, leading to disruption of normal neurological processes and causing the illness clinically described as neurotoxic shellfish poisoning (NSP). PbTx-3 is a potent allosteric voltage-gated Na+ channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain).PbTx-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. PbTx-3 repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.

Store at -20°C. If intended for use within a month, may keep at 4°C. Minimize freeze-thaw cycles.

12 months from the date of shipment when stored properly.