Anti-C2 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Hamster
Host Species	Rabbit
Accession Number	P06681
Gene Id	717
Gene Symbols	C2
Protein Name / Synonyms	C2 (N-term)
Clonality	Polyclonal
Preparation	This C2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-176 amino acids from the N-terminal region of human C2.
Concentration (lot specific)	0.260 mg/ml
Recommended Applications	Western Blotting
Research Area	Autoimmune Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

Specificity

Other Names

C2; Complement C2; C3/C5 convertase; Complement C2b fragment; Complement C2a fragment

NCBI Accession #

NP_000054.2;NP_001139375.1;NP_001171534.1

Other Accession #

NP_000054

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

83268

Recommended Dilutions

WB: 1:1000

C2 Antibody (N-term) (Cat# 102-10740) western blot analysis in CHO cell line lysates (35ug/lane).This demonstrates the C2 antibody detected the C2 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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