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Anti-Calnexin Antibody
Catalog #: 188-10976
Mouse anti-Human Calnexin Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Does not react with rat. Other species not tested. |
| Host Species | Mouse |
| Accession Number | P27824 |
| Gene Id | 821 |
| Gene Symbols | CANX |
| Protein Name / Synonyms | Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90) |
| Immunogen | A partial human recombinant protein was used as the immunogen for the Calnexin antibody. |
| Isotype | Kappa, IgG2b |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | Western Blotting: 0.5-1ug/ml FACS: 0.5-1ug/10^6 cells Immunofluorescence: 0.5-1ug/ml Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cytoplasmic |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
It recognizes a protein of 90kDa, which is identified as Calnexin. Secretory and transmembrane proteins are synthesized on polysomes and translocate into the endoplasmic reticulum (ER) where they are often modified by the formation of disulfide bonds, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including calnexin. It is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.
Storage
Store the Calnexin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.