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Anti-Calretinin Antibody
Catalog #: 130-10089
Rabbit Anti-Human Calretinin Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | P22676 |
| Gene Id | 794 |
| Gene Symbols | CALB2 CAB29 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was recombinant protein from human Calretinin. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Recommended Applications | ELISA (recommended work dilution= 1:640, 000) |
| Antigen Catalog Number | 230-00201 |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Calretinin also known as 29 kDa calbindin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. In humans, the calretinin protein is encoded by the CALB2 gene. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers.
Specificity
The antibody can specifically bind to human Calretinin. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse or rat Calretinin was not tested.
Storage
Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.
Related Products
Sheep Anti-Guinea Pig Calretinin (cat# 129-10333 )Recombinant Mouse Calretinin (cat#228-10161-3 )
References
- Parmentier M, et al (1991). "The human calbindin D28k (CALB1) and calretinin (CALB2) genes are located at 8q21.3----q22.1 and 16q22----q23, respectively, suggesting a common duplication with the carbonic anhydrase isozyme loci". Cytogenet. Cell Genet. 57 (1): 413.
- Poblet E, et al. (2005). "The calcium-binding protein calretinin is a marker of the companion cell layer of the human hair follicle". Br. J. Dermatol. 152 (6): 131620.
Expiration:
12 months from the date of shipment when stored properly.