Anti-CASP6 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P55212
Gene Id	839
Gene Symbols	CASP6
Protein Name / Synonyms	CASP6 (N-term)
Clonality	Polyclonal
Preparation	This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human CASP6.
Concentration (lot specific)	0.410 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Apoptosis, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq].

Specificity

Other Names

CASP6; MCH2; Caspase-6; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11

NCBI Accession #

NP_001217.2;NP_116787.1

Other Accession #

NP_116787.1; NP_001217.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33310

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of CASP6 (arrow) using rabbit polyclonal CASP6 Antibody (N-term) (Cat# 102-12187). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CASP6 gene.
	CASP6 Antibody (N-term) (102-12187)immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CASP6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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