Anti-CCNH (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P51946
Gene Id	902
Gene Symbols	CCNH
Protein Name / Synonyms	CCNH (C-term)
Clonality	Polyclonal
Preparation	This CCNH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-299 amino acids from the C-terminal region of human CCNH.
Concentration (lot specific)	0.250 mg/ml
Recommended Applications	Western Blotting, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. A pseudogene of this gene is found on chromosome 4. Alternate splicing results in multiple transcript variants.

Specificity

Predicted Reactivity

Monkey

Other Names

CCNH; Cyclin-H; MO15-associated protein; p34; p37

NCBI Accession #

NP_001230.1

Other Accession #

Q4R7U4; NP_001230.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

37643

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	CCNH Antibody (C-term) (Cat# 102-10864) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CCNH antibody detected the CCNH protein (arrow).
	CCNH Antibody (C-term) (Cat# 102-10864) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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