Anti-CCNT1 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	O60563
Gene Id	904
Gene Symbols	CCNT1
Protein Name / Synonyms	CCNT1 (Center)
Clonality	Polyclonal
Preparation	This CCNT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids from the Central region of human CCNT1.
Concentration (lot specific)	0.350 mg/ml
Recommended Applications	Western Blotting, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

Specificity

Other Names

CCNT1; Cyclin-T1

NCBI Accession #

NP_001231.2

Other Accession #

NP_001231

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

80685

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	CCNT1 Antibody (Center) (Cat# 102-10745) western blot analysis in mouse testis tissue lysates (35ug/lane).This demonstrates the CCNT1 antibody detected the CCNT1 protein (arrow).
	CCNT1 Antibody (Center) (Cat# 102-10745) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CCNT1 antibody detected the CCNT1 protein (arrow).
	CCNT1 Antibody (Center) (Cat# 102-10745) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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