3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-CD147, azide-free Antibody
Catalog #: DS-MB-02828
Mouse Anti-Human CD147, azide-free (0.1 mg)
Product Description
Specifications
| Size | 0.1 mg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | This product specifically recognizes the Ig domain D2 of human CD147, otherwise known as neurothelin, a type I transmembrane glycoprotein and member of the immunoglobulin gene superfamily, broadly expressed on peripheral blood cells, endothelial cells, and increased on T cells following activation. CD147 is also strongly expressed on small lung cancer cells and hepatocellular carcinoma. Biological properties of CD147 include the regulation of T cells, integrin functions and cell adhesion, the stimulation of metalloproteinase (MMP) production by fibroblasts, the promotion of astrocyte outgrowths, and roles in tumour progression, neuronal system function and reproduction. This product inhibits anti-CD3-induced T cell activation, dependent upon antibody concentration(1 ). |
| Host Species | Mouse |
| Protein Name / Synonyms | CD147 |
| Concentration (lot specific) | IgG concentration 1.0mg/ml |
| Recommended Applications | Flow Cytometry, Functional Assays, Western Blotting |
| Research Area | Adaptive Immunity |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
This product detects a band of approximately 45-60kDa in 293 human fibroblastoid cell lysates under non-reducing conditions.
Storage/Stability
Store at -20 °C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
If stored in this manner, this product is stable for 18 months after receipt.
Format
Supplied as:
Purified IgG - liquid
Formulation:
Phosphate buffered saline
Format Type:
Azide Free
Preparation
Immunogen:
CD147Rg, consisting of the CDNA coding for the hinge region, CH2-and CH3 domain of human IgG1.
Preservative:
None present
This product
Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line.
Expiration:
12 months from the date of shipment when stored properly.