Anti-CFL2 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9Y281
Gene Id	1073
Gene Symbols	CFL2
Protein Name / Synonyms	CFL2 (N-term)
Clonality	Polyclonal
Preparation	This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human CFL2.
Concentration (lot specific)	0.480 mg/ml
Recommended Applications	Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Specificity

Predicted Reactivity

Mouse, Bovine, Pig

Other Names

CFL2; Cofilin-2; Cofilin, muscle isoform

NCBI Accession #

NP_001230574.1;NP_068733.1;NP_619579.1

Other Accession #

Q5G6V9; P45591; Q148F1; NP_619579.1; NP_068733.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

18737

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	Western blot analysis of lysate from NCI-H1299 cell line, using CFL2 Antibody (N-term)(Cat# 102-12319). 102-12319 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
	CFL2 Antibody (N-term) (102-12319)immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CFL2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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