3607 Parkway Ln Ste 200 Norcross, Georgia 30092
www.RayBiotech.com | info@raybiotech.com
770-729-2992 | +1-888-494-8555
ISO 13485:2016 cGMP
Anti-CIRBP (C-term) Antibody
Catalog #: 102-18161
Rabbit Anti-Human CIRBP (C-term) Antibody, 400 ul
Product Description
Specifications
| Size | 400 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | Q14011 |
| Gene Id | 1153 |
| Gene Symbols | CIRBP |
| Protein Name / Synonyms | CIRBP (C-term) |
| Clonality | Polyclonal |
| Preparation | This CIRBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-172 amino acids from the C-terminal region of human CIRBP. |
| Concentration (lot specific) | 0.5 mg/ml |
| Recommended Applications | Western Blotting, IHC-P |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed.
Specificity
Predicted Reactivity
Mouse, Rat, Hamster
Other Names
CIRBP; A18HNRNP; CIRP; Cold-inducible RNA-binding protein; A18 hnRNP; Glycine-rich RNA-binding protein CIRP
NCBI Accession #
NP_001271.1
Other Accession #
P60825; P60824; P60826
Format
Type
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Calculated Molecular Weight (Da)
18648
Recommended Dilutions
WB: 1:1000; IHC: 1:50-100
 | Western blot analysis of CIRBP Antibody (C-term) (Cat# 102-18161) in Y79 cell line lysates (35ug/lane). CIRBP (arrow) was detected using the purified Pab. |
 | CIRBP Antibody (C-term) (Cat# 102-18161) IHC analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CIRBP Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
 | Western blot analysis of CIRBP (arrow) using rabbit polyclonal CIRBP Antibody (C-term) (Cat# 102-18161). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CIRBP gene. |
Antigen Source
HUMAN
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.