Anti-Claudin 1 (CLDN1) (Loop1) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	O95832
Gene Id	9076
Gene Symbols	CLDN1
Protein Name / Synonyms	Claudin 1 (CLDN1) (Loop1)
Clonality	Polyclonal
Preparation	This Claudin 1(CLDN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-82 amino acids from human Claudin 1(CLDN1).
Recommended Applications	Western Blotting, IHC-P
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. CLDN1, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Specificity

Other Names

CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein

NCBI Accession #

NP_066924.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

22744

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	CLDN1 Antibody (Loop1) (Cat# 102-16739) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the CLDN1 antibody detected the CLDN1 protein (arrow).
	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hCLDN1-Loop1 (Cat# 102-16739), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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