Anti-COL1A1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P02452
Gene Id	1277
Gene Symbols	COL1A1
Protein Name / Synonyms	COL1A1 (C-term)
Clonality	Polyclonal
Preparation	This COL1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1077-1106 amino acids from the C-terminal region of human COL1A1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish].

Specificity

Predicted Reactivity

Rat, Bovine, Chicken

Other Names

COL1A1; Collagen alpha-1(I) chain; Alpha-1 type I collagen

NCBI Accession #

NP_000079.2

Other Accession #

P02454; P11087; P02457; P02453; NP_000079.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

138941

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50

	COL1A1 Antibody (C-term) (Cat# 102-12506) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the COL1A1 antibody detected the COL1A1 protein (arrow).
	COL1A1 Antibody (C-term) (Cat# 102-12506)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of COL1A1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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