Anti-CPT1C (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q8TCG5
Gene Id	126129
Gene Symbols	CPT1C
Protein Name / Synonyms	CPT1C (C-term)
Clonality	Polyclonal
Preparation	This CPT1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 752-782 amino acids from the C-terminal region of human CPT1C.
Concentration (lot specific)	0.250 mg/ml
Recommended Applications	Western Blotting, FC
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.

Specificity

Other Names

CPT1C; CATL1; Carnitine O-palmitoyltransferase 1, brain isoform; CPT IC; Carnitine O-palmitoyltransferase I, brain isoform; Carnitine palmitoyltransferase 1C

NCBI Accession #

NP_001129524.1;NP_001186681.1;NP_001186682.1;NP_689572.1

Other Accession #

NP_001129524.1; NP_689572.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

90989

Recommended Dilutions

WB: 1:1000; FC: 1:10-50

	CPT1C Antibody (C-term) (Cat# 102-11105) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the CPT1C antibody detected the CPT1C protein (arrow).
	CPT1C Antibody (C-term) (Cat# 102-11105) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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