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Anti-Cyclin D1 Antibody, PE
Catalog #: 188-11305-PE
Mouse anti-Human Cyclin D1 Antibody [PE Conjugated]
Product Description
Specifications
| Size | 100 tests |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P24385 |
| Gene Id | 595 |
| Gene Symbols | CCND1,BCL1,PRAD1 |
| Protein Name / Synonyms | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene) |
| Immunogen | Human recombinant full length Cyclin D1 protein was used as the immunogen. |
| Isotype | Kappa, IgG2a |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 500 ul at 0.1 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | Flow Cytometry: 5ul/test/million cells or 5ul/test/100ul of whole blood Immunofluorescence: 1:50-1:100 for 30 minutes at RT |
| Domain / Region / Terminus | Nuclear |
| Research Area | Cancer, Cell Cycle |
| Shipping Type | Blue ice |
| Storage | 2-8°C |
Description
Description
This antibody recognizes a protein of 36kDa, identified as Cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression. The antibody is useful in identifying mantle cell lymphomas (Cyclin D1 positive) from CLL/SLL and follicular lymphomas (Cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Storage
Store the Cyclin D1 antibody at 2-8°C. Conjugate is light sensitive, store in the dark.
Expiration:
12 months from the date of shipment when stored properly.