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Anti-Cyclin D3 (Phospho-Thr283) Antibody
Catalog #: 102-26338
Rabbit Anti-Cyclin D3 (Phospho-Thr283) Antibody, 100 µl
Product Description
Specifications
| Size | 100 µL |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Host Species | Rabbit |
| Accession Number | P30281 |
| Gene Id | 896 |
| Gene Symbols | CCND3 |
| Protein Name / Synonyms | G1/S-specific cyclin-D3, CCND3 |
| Clonality | Polyclonal |
| Recommended Applications | Western Blotting, IHC |
| Research Area | Cell Cycle |
| Shipping Type | Blue ice |
| Storage | -20°C |
Description
Introduction
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Other Information
Antigen Type
synthetic peptide
Images
WB (1:1000)
Western blot analysis of extracts from K562 cells treated with UV (5mins), using Cyclin D3 (Phospho-Thr283) Antibody (#A0418).
IHC (1:50~100)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Cyclin D3 (Phospho-Thr283) Antibody (#A0418).
Storage/Stability
2-8°C (short-term); -20°C (long-term)
Expiration:
12 months from the date of shipment when stored properly.