Anti-CYP2B6 (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P20813
Gene Id	1555
Gene Symbols	CYP2B6
Protein Name / Synonyms	CYP2B6 (Center)
Clonality	Polyclonal
Preparation	This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.
Concentration (lot specific)	0.360 mg/ml
Recommended Applications	IF, Western Blotting, IHC-P
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.

Specificity

Other Names

CYP2B6; Cytochrome P450 2B6; CYPIIB6; Cytochrome P450 IIB1

NCBI Accession #

NP_000758.1

Other Accession #

NP_000758.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

56278

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	CYP2B6 Antibody (Center) (Cat# 102-10938) western blot analysis in 293(lane 1) and K562(lane 2) cell line lysates (35ug/lane).This demonstrates the CYP2B6 antibody detected the CYP2B6 protein (arrow).
	CYP2B6 Antibody (Center) (Cat# 102-10938)immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CYP2B6 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of CYP2B6 Antibody (Center)(Cat# 102-10938) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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