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ISO 13485:2016 cGMP
Anti-DC-SIGN / CD209 Antibody, Sodium Azide Free
Catalog #: 188-11207-SAF
Mouse anti-Human DC-SIGN Antibody / CD209 [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | Q9NNX6 |
| Gene Id | 30835 |
| Gene Symbols | CD209,CLEC4L |
| Protein Name / Synonyms | CD209 antigen (C-type lectin domain family 4 member L) (Dendritic cell-specific ICAM-3-grabbing non-integrin 1) (DC-SIGN) (DC-SIGN1) (CD antigen CD209) |
| Immunogen | A human partial recombinant protein was used as the immunogen for the DC-SIGN antibody. |
| Isotype | Kappa, IgG2b |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | IF: 1-2 ug/ml Flow Cytometry: 0.5-1ug/million cells in 0.1ml IHC (FFPE): 0.5-1ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cytoplasmic, membranous, secreted |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
DC-SIGN / CD209 is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.
Storage
Store the DC-SIGN antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.