This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.

WB 1:500 - 1:2000; IHC 1:50 - 1:100; IF 1:50 - 1:100

Recombinant fusion protein containing a sequence corresponding to amino acids 31-359 of human DCN (NP_598010.1).

Unmodified

Store at -20°. Avoid freeze / thaw cycles.