Anti-DTNA (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Mouse
Host Species	Rabbit
Accession Number	Q9Y4J8
Gene Id	1837
Gene Symbols	DTNA
Protein Name / Synonyms	DTNA (C-term)
Clonality	Polyclonal
Preparation	This DTNA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 692-721 amino acids from the C-terminal region of human DTNA.
Concentration (lot specific)	0.380 mg/ml
Recommended Applications	Western Blotting, IHC-P, IF
Research Area	Cardiovascular Disease, Inflammation
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Specificity

Other Names

DTNA; DRP3; Dystrobrevin alpha; Alpha-dystrobrevin; Dystrophin-related protein 3

NCBI Accession #

NP_001121647.1;NP_001185867.1;NP_001185868.1;NP_001185869.1;NP_001185871.1;NP_001185873.1;NP_001185874.1;NP_001381.2;NP_001382.2;NP_001383.2;NP_116757.2;NP_116760.2;NP_116761.2;NP_116762.2;NP_116763.1

Other Accession #

NP_116760.2; NP_001383.2

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

83901

Recommended Dilutions

WB: 1:1000; IHC: 1:10-50; IF: 1:10-50

	DTNA Antibody (C-term) (Cat# 102-11635) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DTNA antibody detected the DTNA protein (arrow).
	DTNA Antibody (C-term) (Cat# 102-11635)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DTNA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	Confocal immunofluorescent analysis of DTNA Antibody (C-term) (Cat# 102-11635) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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