Anti-ERCC1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse
Host Species	Rabbit
Accession Number	P07992
Gene Id	2067
Gene Symbols	ERCC1
Protein Name / Synonyms	ERCC1 (C-term)
Clonality	Polyclonal
Preparation	This ERCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-297 amino acids from the C-terminal region of human ERCC1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.

Specificity

Other Names

ERCC1; DNA excision repair protein ERCC-1

NCBI Accession #

NP_001159521.1;NP_001974.1;NP_973730.1

Other Accession #

NP_001974.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

32562

Recommended Dilutions

WB: 1:1000

	ERCC1 Antibody (C-term) (Cat# 102-12310) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the ERCC1 antibody detected the ERCC1 protein (arrow).
	ERCC1 Antibody (C-term) (Cat# 102-12310) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the ERCC1 antibody detected the ERCC1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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