Anti-ERVWE1 (C-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q9UQF0
Gene Id	30816
Gene Symbols	ERVW-1
Protein Name / Synonyms	ERVWE1 (C-term)
Clonality	Polyclonal
Preparation	This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Specificity

Other Names

ERVW-1; ERVWE1; HERV-W_7q21.2 provirus ancestral Env polyprotein; Endogenous retrovirus group W member 1; Env-W; Envelope polyprotein gPr73; Enverin; HERV-7q Envelope protein; HERV-W envelope protein; Syncytin; Syncytin-1; Surface protein; gp50; Transmembrane protein; gp24

NCBI Accession #

NP_001124397.1;NP_055405.3

Other Accession #

NP_055405.3; NP_001124397.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

59866

Recommended Dilutions

WB: 1:1000

ERVWE1 Antibody (C-term) (Cat# 102-13245) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the ERVWE1 antibody detected the ERVWE1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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