Anti-EXOSC6 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q5RKV6
Gene Id	118460
Gene Symbols	EXOSC6
Protein Name / Synonyms	EXOSC6 (N-term)
Clonality	Polyclonal
Preparation	This EXOSC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-38 amino acids from the N-terminal region of human EXOSC6.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene product constitutes one of the subunits of the multisubunit particle called exosome, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.

Specificity

Other Names

EXOSC6; MTR3; Exosome complex component MTR3; Exosome component 6; mRNA transport regulator 3 homolog; p11

NCBI Accession #

NP_478126.1

Other Accession #

NP_478126.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

28235

Recommended Dilutions

WB: 1:1000

EXOSC6 Antibody (N-term) (Cat# 102-14125) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the EXOSC6 antibody detected the EXOSC6 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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