Anti-FBL (Center E120) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P22087
Gene Id	2091
Gene Symbols	FBL
Protein Name / Synonyms	FBL (Center E120)
Clonality	Polyclonal
Preparation	This FBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-135 amino acids from the Central region of human FBL.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

FBL is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. This protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

FBL; FIB1; FLRN; rRNA 2'-O-methyltransferase fibrillarin; 34 kDa nucleolar scleroderma antigen

NCBI Accession #

NP_001427.2

Other Accession #

P22509; P35550

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

33784

Recommended Dilutions

WB: 1:1000

Western blot analysis of anti-FBL Antibody (Center E120) (Cat# 102-15134) in K562 cell line lysates (35ug/lane). FBL (arrow) was detected using the purified Pab.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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