Anti-FDPS (Center) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P14324
Gene Id	2224
Gene Symbols	FDPS
Protein Name / Synonyms	FDPS (Center)
Clonality	Polyclonal
Preparation	This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-419 amino acids from the center region of human FDPS.
Concentration (lot specific)	2.0 mg/ml
Recommended Applications	Western Blotting, IHC-P
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes.1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.

Specificity

Other Names

FDPS; FPS; KIAA1293; Farnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase

NCBI Accession #

NP_001129293.1;NP_001129294.1;NP_001229753.1;NP_001229754.1;NP_001995.1

Format

Type

Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

48275

Recommended Dilutions

IHC: 1:10-50; WB: 1:1000

	Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with FDPS antibody (Center )(Cat# 102-15034), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
	The anti-FDPS Pab (Cat# 102-15034) is used in Western blot to detect FDPS in human cytokeratin liver cell lysate. Data is kindly provided by Dr. Masaru Harada from Stanford University (Palo Alto, CA).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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