Anti-FDPS (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	P14324
Gene Id	2224
Gene Symbols	FDPS
Protein Name / Synonyms	FDPS (N-term)
Clonality	Polyclonal
Preparation	This FDPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human FDPS.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	Western Blotting
Research Area	Cancer
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Specificity

Other Names

FDPS; FPS; KIAA1293; Farnesyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase

NCBI Accession #

NP_001129293.1;NP_001129294.1;NP_001229753.1;NP_001229754.1;NP_001995.1

Other Accession #

NP_001129293.1; NP_001129294.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

48275

Recommended Dilutions

WB: 1:1000

	FDPS Antibody (N-term) (Cat# 102-12696) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the FDPS antibody detected the FDPS protein (arrow).
	Western blot analysis of FDPS (arrow) using rabbit polyclonal FDPS Antibody (N-term) (Cat# 102-12696). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FDPS gene.

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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