Anti-FGFRL1 (N-term) Antibody

Product Description

Specifications

Size	400 µL
Estimated Lead Time	1-2 weeks
Species	Human
Host Species	Rabbit
Accession Number	Q8N441
Gene Id	53834
Gene Symbols	FGFRL1
Protein Name / Synonyms	FGFRL1 (N-term)
Clonality	Polyclonal
Preparation	This FGFRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of human FGFRL1.
Concentration (lot specific)	0.5 mg/ml
Recommended Applications	IHC-P, Western Blotting
Research Area	Cardiovascular Disease
Shipping Type	Blue ice
Storage	-20°C

Description

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Specificity

Predicted Reactivity

Mouse, Rat

Other Names

FGFRL1; FGFR5; FHFR; Fibroblast growth factor receptor-like 1; FGF homologous factor receptor; FGFR-like protein; Fibroblast growth factor receptor 5

NCBI Accession #

NP_001004356.1;NP_001004358.1;NP_068742.2

Other Accession #

Q7TQM3; Q91V87; NP_001004358.1

Format

Type

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Calculated Molecular Weight (Da)

54537

Recommended Dilutions

IHC: 1:10-50; WB: 1:1000

	FGFRL1 Antibody (N-term) (Cat# 102-11702)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FGFRL1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
	FGFRL1 Antibody (N-term) (Cat# 102-11702) western blot analysis in A549,HepG2,Y79 cell line lysates (35ug/lane).This demonstrates the FGFRL1 antibody detected the FGFRL1 protein (arrow).

Antigen Source

HUMAN

Storage/Stability

2-8°C (short-term); -20°C (long-term)

Expiration:

12 months from the date of shipment when stored properly.

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