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Anti-Fibronectin Antibody, Sodium Azide Free
Catalog #: 188-10090-SAF
Mouse anti-Human/Pig/Mouse/Rat Fibronectin Antibody [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P02751 |
| Gene Id | 2335 |
| Gene Symbols | FN1,FN |
| Protein Name / Synonyms | Fibronectin (FN) (Cold-insoluble globulin) (CIG) [Cleaved into: Anastellin, Ugl-Y1, Ugl-Y2, Ugl-Y3] |
| Immunogen | A T-cell lymphoma biopsy was used as the immunogen for this fibronectin antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS (pH 7.4), BSA free, sodium azide free |
| Recommended Applications | FACS: 0.5-1ug/million cells IF: 0.5-1ug/ml IHC (FFPE): 0.5-1ug/ml for 30 minutes at RT (1) |
| Domain / Region / Terminus | Connective tissue matrix |
| Research Area | Angiogenesis, Cardiovascular Disease, Cell Adhesion |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Fibronectin is a soluble dimeric glycoprotein of 440kDa, which is present in cells, extracellular matrix, and blood. There are two types of fibronectin: soluble fibronectin which is produced by hepatocytes and found in blood plasma, and insoluble cellular fibronectin which is produced by fibroblasts in a soluble form and latter assembled into an insoluble form via fibril formation.
This antibody reacts with the cellular as well as plasma form of fibronectin. Reportedly, after iv administration, this antibody localizes to tumor vessels where it binds to the underlying basement. The Fibronectin epitope recognized by this antibody is not accessible in normal tissues to the circulating antibody indicating that it can be used to specifically target tumor vessels in vivo. Clone TV-1 fibronectin antibody is reportedly useful for delivering vasoactive agents to tumors to induce increased vascular permeability or blood flow prior to treatment with chemotherapeutic drugs or antibodies.
Storage
Store the Fibronectin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.