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Anti-Filaggrin Antibody, Sodium Azide Free
Catalog #: 188-11100-SAF
Mouse anti-Human Filaggrin Antibody [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P20930 |
| Gene Id | 2312 |
| Gene Symbols | FLG |
| Protein Name / Synonyms | Filaggrin |
| Immunogen | Amino acids 998-1104 of human FLG were used as the immunogen for this Filaggrin antibody. |
| Isotype | IgG |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | FACS: 0.5-1ug/10^6 cells in 0.1ml IF: 1-2ug/ml IHC (FFPE): 0.5-1ug/ml for 30 min at RT |
| Domain / Region / Terminus | Cytoplasmic |
| Research Area | Inflammation |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Filaggrin (FLG) is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple Filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional Filaggrin molecules. Active Filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
Storage
Store the Filaggrin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.