Anti-FMR1 Antibody

Product Description

Specifications

Size	20 µL, 100 µL
Estimated Lead Time	1-2 weeks
Species	Human, Mouse, Rat
Host Species	Rabbit
Accession Number	Q06787
Gene Id	2332
Gene Symbols	FMR1
Protein Name / Synonyms	FMR1, FMRP, FRAXA, POF, POF1, POFX, fragile X mental retardation 1
Clonality	Polyclonal
Isotype	IgG
Purity	Affinity purification
Buffers	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Recommended Applications	Western Blotting, IHC
Shipping Type	Blue ice
Storage	-20°C

Description

Background

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Dilutions

WB 1:500 - 1:1000
IHC 1:50 - 1:200

Format

Calculated MW

58kDa/61kDa/66kDa/68kDa/69kDa/70kDa/71kDa

Observed MW

75kDa

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 500-600 of human FMR1 (NP_002015.1).

Modification

Unmodified

Storage

-20°C

Images

Western blot analysis of extracts of various cell lines, using FMR1 antibody (144-06092) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
Western blot - FMR1 Polyclonal Antibody (144-06092)

Expiration:

12 months from the date of shipment when stored properly.

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