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Anti-Galectin-3 Antibody
Catalog #: 130-10090
Rabbit Anti-Human Galectin-3 Antibody
Product Description
Specifications
| Size | 20 µg, 100 µg, 200 µg, 500 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Accession Number | P17931 |
| Gene Id | 3958 |
| Gene Symbols | LGALS3 MAC2 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was recombinant protein from human Galectin-3. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Recommended Applications | ELISA (recommended work dilution= 1:320, 000) |
| Antigen Catalog Number | 230-00202 |
| Reconstitution | Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile water to a final concentration of 1 mg/ml. |
| Research Area | Cardiovascular Disease |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition binding domain (CRD) of about 130 amino acids that enable the specific binding of beta-galactosides. Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21q22. This protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3/LGALS3 can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands.
Specificity
The antibody can specifically bind to human Galectin-3. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse or rat Galectin-3 was not tested.
Storage
Store at 4°C if intended for use within one month, otherwise, store at -20°C to -80°C. The lyophilized antibody is stable for at least 18 months after the date of receipt when stored at -20°C to -80°C. After reconstitution, it can be aliquoted and stored frozen at -20°C to -80°C in a manual defrost freezer for at least 6 months without detectable loss of activity. Upon reconstitution, the antibody can also be stored for 1 month at 4°C. Please avoid freeze-thaw cycles, as this will lower the activity of the antibody.
Related Products
Rabbit Anti-Human Galectin-3 / LGALS3 (cat# DS-PB-02616 )Recombinant Human Galectin-3 / LGALS3, E.coli-derived (cat#230-00202)
References
- Dumic J, Dabelic S, Flögel M. (2006). "Galectin-3: an open-ended story." Biochim Biophys Acta 1760 (4): 616635.
- Liu F, Patterson RJ, Wang JL. (2002). "Intracellular function of galectins." Biochim Biophys Acta 1572 (2-3): 263273.
- Raimond J, et al. (1997). "Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q2122." Mamm Genome 8 (9): 706707.
Expiration:
12 months from the date of shipment when stored properly.