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Anti-Galectin-3 Antibody, Biotinylated
Catalog #: 130-10090B-50
Rabbit anti-Galectin-3 Biotinylated Antibody, 50 ug
Product Description
Specifications
| Size | 50 µg |
| Estimated Lead Time | 1-2 business days |
| Species | Human |
| Host Species | Rabbit |
| Accession Number | P17931 |
| Gene Id | 3958 |
| Gene Symbols | LGALS3 MAC2 |
| Clonality | Polyclonal |
| Immunogen | Immunogen was recombinant protein from human Galectin-3. This antibody was produced from a rabbit immunized with the immunogen. The IgG fraction was purified from rabbit serum followed by Protein A/G affinity chromatography. |
| Isotype | IgG |
| Recommended Applications | ELISA (recommended work dilution= 1:320, 000) |
| Reconstitution | A separate vial of dilution buffer is provided for reconstitution. The antibody is supplied lyophilized, originally containing PBS, without preservative stabilizers (e.g. sodium azide). The final amount is indicated on the shipping vial. |
| Research Area | Cardiovascular Disease |
| Shipping Type | Ambient temperature |
| Storage | -20°C |
Description
Description
Galectin-3 is a member of the lectin family, of which 14 mammalian galectins have been identified. Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition binding domain (CRD) of about 130 amino acids that enable the specific binding of beta-galactosides. Galectin-3 is encoded by a single gene, LGALS3, located on chromosome 14, locus q21q22. This protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3/LGALS3 can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands.
Storage / Stability
The antibody is stable for at least 1 year from the date of receipt when stored at -20°C to -70°C. Reconstituted antibody can also be aliquotted and stored at 4°C for 1 month or at -20°C to -70°C in a manual defrost freezer for many months without detectable loss activity. Please avoid freeze-thaw cycles.
Specificity
The antibody can specifically bind to human Galectin-3. The specificity for binding to recombinant protein, cellular protein and native antigen is not defined. Cross reactivity with mouse or rat Galectin-3 was not tested.
Related Products
Rabbit Anti-Human Galectin-3 / LGALS3 (cat# DS-PB-02616 )Recombinant Human Galectin-3 / LGALS3, E.coli-derived (cat#230-00202)
References
- Dumic J, Dabelic S, Fl¶gel M. (2006). "Galectin-3: an open-ended story." Biochim Biophys Acta 1760 (4): 616635.
- Liu F, Patterson RJ, Wang JL. (2002). "Intracellular function of galectins." Biochim Biophys Acta 1572 (2-3): 263273.
- Raimond J, et al. (1997). "Mapping of the galectin-3 gene (LGALS3) to human chromosome 14 at region 14q2122." Mamm Genome 8 (9): 706707.
Expiration:
12 months from the date of shipment when stored properly.