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Anti-Gamma Catenin / Plakoglobin Antibody
Catalog #: 188-11010
Mouse anti-Human Gamma Catenin Antibody / Plakoglobin
Product Description
Specifications
| Size | 20 µg, 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | P14923 |
| Gene Id | 3728 |
| Gene Symbols | JUP,CTNNG,DP3 |
| Protein Name / Synonyms | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) |
| Immunogen | Recombinant human protein was used as the immunogen for the Plakoglobin antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | Immunofluorescence: 1-2ug/ml Western Blotting: 0.5-1ug/ml FACS: 0.5-1ug/10e6 cells in 0.1ml IHC (FFPE): 0.1-0.2ug/ml |
| Domain / Region / Terminus | Cell surface, cytoplasmic, cell junctions |
| Research Area | Angiogenesis, Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Plakoglobin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris.
Plakoglobin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Plakoglobin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki]
Storage
Store the Plakoglobin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.