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Anti-Gamma Catenin / Plakoglobin Antibody, Sodium Azide Free
Catalog #: 188-10982-SAF
Mouse anti-Human/Mouse/Rat/Cat/Dog/Chicken/Cow Gamma Catenin Antibody / Plakoglobin [Sodium Azide Free]
Product Description
Specifications
| Size | 100 µg |
| Estimated Lead Time | 1-2 weeks |
| Species | Human, Mouse, Rat |
| Specificity | Other species not tested. |
| Host Species | Mouse |
| Accession Number | P14923 |
| Gene Id | 3728 |
| Gene Symbols | JUP,CTNNG,DP3 |
| Protein Name / Synonyms | Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3) |
| Immunogen | Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 1 mg/ml in 1X PBS, BSA free, sodium azide free |
| Recommended Applications | Immunofluorescence: 1-2ug/ml Western Blotting: 0.5-1ug/ml Immunoprecipitation: suitable |
| Domain / Region / Terminus | Cell surface, cytoplasmic, cell junctions |
| Research Area | Angiogenesis, Cardiovascular Disease |
| Shipping Type | Blue ice |
| Storage | ≤-20°C |
Description
Description
Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]
Storage
Store the Plakoglobin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Expiration:
12 months from the date of shipment when stored properly.